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Modafinil is one of the most popular drugs from the group of so-called "smart" drugs, which are taken to improve performance and enhance the brain's cognitive functions. This agent is especially popular among people whose work is associated with mental work or requires increased concentration. In particular, this drug is prevalent among students, IT-specialists, truckers.

However, despite the immense popularity of Modafinil, many still refuse to take it for fear of possible side effects.

What is Modafinil?


Modafinil's primary function is to help people with sleep disorders stay active and awake throughout the day. First of all, we are talking about people with narcolepsy and suffering from excessive daytime sleepiness due to obstructive sleep apnea syndrome. It is prescribed for patients with multiple sclerosis, clinical depression, Parkinson's disease, psychiatric disorders, and cognitive impairments [1].

By acting on the cells of the brain, this drug helps to improve cognitive functions. In particular, Modafinil causes an increase in performance, activity, alertness, focus, and concentration. Therefore, many perceive it as a kind of doping for the brain.


How does Modafinil work?

Scientists are still continuing to study the mechanism of action of Modafinil on the human body. Today it is known that the drug affects various neurotransmitters in the brain, which are responsible for quick wits, concentration, and focus. It is believed to affect several different pathways in the brain and thereby create a stimulating effect and enhance cognitive function.


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Modafinil activates the production of dopamine in the brain. Therefore, this drug is prescribed for people with hyperactivity (ADHD), whose dopamine level is critically low, which is why there are problems with concentration and impaired attention.

During clinical studies, Modafinil was found to have neuroprotective and antioxidant properties. It increases the level of cortical creatine and, at the same time, reduces oxidative processes in the brain, which also helps to improve concentration. In addition, it inhibits the activity of compounds that are responsible for fatigue and, conversely, activates substances that promote wakefulness.


How long does it take for the drug to take effect?

In most cases, the effect of Modafinil can be felt within about half an hour - an hour after taking it. But this indicator can vary depending on the individual characteristics of the organism.

 

Period of action


The rate of absorption of this agent can be influenced by age, body weight, diet, and the presence of certain diseases. So, in overweight people, the absorption of this substance occurs more slowly than in thin people. In addition, if a hearty meal preceded the pill, Modafinil will also work later than if taken on an empty stomach. However, the latter should not be practiced so as not to irritate the mucous membrane of the digestive organs.


How long does it last?

The duration of action of Modafinil is, on average, 16 to 22 hours. This indicator can also vary depending on the individual characteristics of the organism. The substance reaches its maximum concentration in the blood approximately 45-120 minutes after ingestion. The strongest effect of the drug is felt between 4 and 6 hours after use. The half-life of a substance from the body is from 12 to 15 hours.

Taking some medications that affect metabolic processes can also affect the half-life of Modafinil. In some cases, the effect of the drug lasts up to 22 hours.


Side effects of the drug


As a rule, Modafinil does not cause serious side effects. Sometimes, against the background of very high doses of the drug or due to individual intolerance, side effects such as:

  1.     headache;
  2.     diarrhea;
  3.     indigestion;
  4.     sleep disturbance;
  5.     dizziness;
  6.     back pain;
  7.     nausea.

Although most people do not experience any side effects while taking this drug, we recommend that you consult with your doctor before taking it.

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