As a pediatrician, I am often asked about the best choice between Tylenol (acetaminophen) and Motrin/Advil (Ibuprofen) for children. Both medications are effective at relieving pain and reducing fever, but some key differences guide my recommendations based on a child’s specific needs.

Infants/Newborns Under Two Months:

First and foremost, we do not recommend using any fever-reducing medications without the advice of a medical provider until your baby is two months of age.  

Infants/Newborns Under Six Months: 

Advil/Motrin (ibuprofen) is not recommended for children less than six months of age, so stick to acetaminophen until then.

Tylenol (Acetaminophen) is a good choice for mild to moderate pain relief or when treating fever in children. It’s generally very gentle on the stomach, which makes it a good option for children who may have a sensitive tummy or those who are prone to stomach issues, such as vomiting or acid reflux.  Tylenol is safe for most children when taken as directed, and it’s often a go-to when we want to focus on fever reduction or pain relief without worrying about inflammation. Acetaminophen can be dosed once every 4-6 hours, with no more than five doses in a day. 

Children’s Tylenol (Acetaminophen) comes in one strength (160mg/5ml), which can make dosing a little more straightforward.

Motrin/Advil  (Ibuprofen), on the other hand, is a great option if a child is experiencing inflammation, more significant discomfort, such as from teething, muscle aches, higher fever, or an injury. Ibuprofen tends to have a longer duration of action—lasting about 6 to 8 hours—so it can help manage discomfort over a longer period. However, it’s important to note that Ibuprofren can sometimes be harder on the stomach, especially if taken on an empty stomach. This is why I recommend giving it with food to reduce the risk of stomach upset. Ibuprofen can be dosed once every six hours, with no more than four doses in a day.

Motrin/ Advil (ibuprofen) comes in two strengths. The “infant strength”  is 50mg/1.25ml vs the “children’s strength”  which is 100mg/ 5ml. To be clear- the infant version is MORE CONCENTRATED, resulting in a lower volume of medication administered.

In some cases, parents will use both medications, alternating between acetaminophen and ibuprofen. This can be effective for managing fever and pain, but it’s important to space the doses appropriately and ensure you’re not exceeding the maximum daily doses for either medication. If you’re ever uncertain, MVP is always happy to help guide you through what’s safest and most effective for your child’s specific situation.

As always, follow the dosing instructions carefully, and never hesitate to reach out if you have any questions about which medication is best for your child. For your ease MVP has provided a dosing calculator that can be helpful when trying to figure out dosages.